The role of (DCE-MRI) for tumour diagnosis and assessment of PI-RADS

The role of Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) for tumour diagnosis and assessment in the current version of PI-RADS (version 2) is minimized. DCE-MRI is only considered when DWI in the peripheral zone (PZ) is indeterminate. 
Although, DCE Perfusion has shown potential in prostate cancer detection, localization and staging, assessment of tumour aggressiveness and assessment of treatment response.
Figure shows a patient with elevated PSA and a very suspicious area in the transition zone with low signal on T2-w, diffusion restriction and high perfusion and permeability, as indicated by the quantitative analysis of DCE-MRI data.
Note that ktrans is the influx mass transfer rate of gadolinium (ktrans depends on blood flow, capillary surface area, and capillary permeability), and kep is the corresponding efflux rate of gadolinium from the extravascular-extracellular space (EES) back into plasma.

The role of (DCE-MRI) for tumour diagnosis and assessment of PI-RADS

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