Dynamic Contrast-Enhanced Perfusion-Weighted Imaging (DCE PWI) “permeability” MRI

Dynamic Contrast-Enhanced Perfusion-Weighted Imaging (DCE PWI), also widely referred to as “permeability” MRI, is based on the acquisition of serial T1-weighted images before, during, and after the administration of gadolinium-based contrast agent. The resulting signal intensity – time curve reflects a composite of tissue perfusion, vessel permeability, and extravascular-extracellular space.
In contrast with conventional contrast-enhanced MRI, which simply displays contrast enhancement at a single point in time, DCE Perfusion imaging depicts the wash-in, plateau and washout contrast kinetics of the tissue, thereby providing insight into the nature of the bulk tissue properties at the microvascular level.
After pharmacokinetic modeling of DCE MR perfusion data, several metrics are commonly derived: the transfer constant (ktrans), the fractional volume of the extravascular-extracellular space (ve), the rate constant (kep, where kep = ktrans/ve), and the fractional volume of the plasma space (vp).

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